SOCS相关论文
研究背景Th17细胞分泌的细胞因子IL-17介导了非嗜酸性粒细胞性哮喘（NEA）的中性粒细胞浸润为主的气道炎症。IL-6诱导STAT3磷酸化,是调......
Comparision of volatile and semivolatile compounds in different partsof Prunella vulgaris (Labiatae)
Plants contain many kinds of volatile and semivolatile chemicals which play an important role in their life cycles.The c......
Background: Interferon α(IFN-α) activated cellular sign- aling is negatively regulated by inhibitory factors, includin......
目的:初步探讨早孕母胎界面细胞因子信号抑制因子3(SOCS3)的作用。方法:26例妊娠35-49d先兆流产患者,采用RT-PCR法及Western blott......
AIM:to analyze adipokine concentrations,insulin resistance and hepatic expression of suppressor of cytokine signaling 3(......
Recently, suppressor of cytokine signaling-3(SOCS3) has been shown to be an inducible endogenous negative regulator of J......
目的模拟肥胖者体内高瘦素环境,探讨瘦素处理脂肪细胞细胞因子信号转导抑制因子3(SOCS-3)mRNA及蛋白表达变化。方法分离SD雄性大鼠......
胰岛素抵抗和脂质代谢异常是2型糖尿病发生的主要原因.胰岛素和炎症信号通路在胰岛素抵抗和脂肪积累中起重要作用.接头蛋白可以介......
The suppressor of cytokine signalling 2(SOCS2),traumatic brain injury and microglial/macrophage regu
Traumatic brain injury(TBI)results in a range of neuroinflammatory events that vary depending on the type and extent of ......
AIM:To investigate the correlation between gastric cancer growth and signal transducer and activator of transcription-3(......
目的:探讨呼吸道合胞病毒(RSV)感染上皮细胞中抗病毒信号激活以及细胞因子负调节系统对细胞因子分泌的影响。方法:应用ELISA法检测......
目的:研究呼吸道合胞病毒(RSV)对细胞因子信号抑制因子(SOCS)3,Toll样受体(TLR)3、TLR4 mR-NA表达影响,探讨SOCS3在病毒感染上皮细......
Albaconol,a Plant-Derived Small Molecule,Inhibits Macrophage Function by Suppressing NF-κB Activatio
Discovery and functional identification of plant-derived small compounds as the immunosuppressant attract much attention......
目的:考察肺痈宁方辅助治疗对肺炎支原体肺炎(MPP)患儿早期血清中s IL-2R、IL-6与外周血单个核细胞SOCS3表达的影响。方法:收集201......
肥胖症是近年来发病率迅速增长的一种代谢病,已经成为一个严重的公共卫生问题,备受关注。本年度Banting奖获得者Flier教授对肥胖症......
细胞因子信号转导抑制因子3(SOCS-3)是白细胞介素6(IL-6)信号转导的负调节因子.研究发现血清IL-6水平与胰岛素抵抗相关,而且可以诱......
妊娠期肝内胆汁淤积症(ICP)是妊娠期特有的并发症,临床上以皮肤瘙痒、肝内胆汁淤积的血液学指标异常为特征,其主要病理学改变是胆......
细胞因子信号转导抑制因子3(SOCS3)通过调节细胞因子信号传导通路对多种细胞及细胞因子具有调节作用,是炎症和细胞凋亡的关键调节......
新近发现的细胞因子信号转导抑制因子(SOCS)家族,因其能够通过Janus激酶—信号传导和转录激活子(JAK-STAT)信号传导通路来反馈调节......
目的:探讨JAK/STAT信号通路相关基因的mRNA表达水平与系统性红斑狼疮(systemic lupus erythematosus,SLE)的关联。方法:以SLE新发......
该文探讨了细胞因子信号传导抑制蛋白1(suppressors of cytokine sigmaling 1,SOCS1)在糖尿病小鼠肾小管间质病变中的作用。通过腹......
目的观察SOCS1基因沉默的DC疫苗对荷黑素瘤小鼠的抗肿瘤作用及肿瘤微环境中IL-10对该DC疫苗抗瘤作用的影响。方法从小鼠股骨分离骨......
CYP2J2-derived EETs attenuated Angiotensin Ⅱ-induced adventitial remodeling via reduced inflammatory
BACKGROUND: Cytochrome P450( CYP) epoxygenases metabolize arachidonic acids( AA) to form epoxyeicosatrienoic acids (EETs......
动脉粥样硬化是多因素疾病,也是心脑血管疾病的重要病理基础.JAK/STAT信号通路与动脉粥样硬化的发生、发展以及防治密切相关,本文......
目的:探讨活性维生素D[1,25-二羟维生素D_3(1,25-dihydroxy vitamin D_3,1,25-(OH)_2VD_3)]通过维生素D受体(Vitamin D receptor,V......
MicroRNAs (miRNAs) have been demonstrated to play an important role in regulation of the immuno- inflammatory response; ......
目的探讨Behet病患者外周血单核细胞(peripheral blood mononuclear cell,PBMC)细胞因子信号抑制因子(sup-pressor of cytokine ......
Suppressor of cytokine signaling 3 (SOCS3) was reported as a feedback inhibitor of cytokine receptor signaling byinhibi......
Mapping Soil Organic Carbon Stocks of Northeastern China Using Expert Knowledge and GIS-based Method
The main aim of this paper was to calculate soil organic carbon stock(SOCS) with consideration of the pedogenetic horizo......
脓毒症是由感染引起的炎性反应综合征,免疫系统在其发展转归中发挥重要作用,细胞因子信号转导抑制物通过调节宿主免疫细胞与病原体......
Spatiotemporal variation of soil organic carbon in the cultivated soil layer of dry land in the Sout
The dynamics of soil organic carbon(SOC)in cropland is one of the central issues related to both soil fertility and envi......
AIM: To pharmacologically modulate Th polarization in the ileum exposed to ionizing radiation by using the immuno-modula......
AIM: To study the role of the intracellular receptor domain of gp130 in human inflammatory bowel disease (IBD). METHODS:......
Clinical significance of mucosal suppressors of cytokine signaling 3 expression in ulcerative coliti
AIM:To investigate the clinical significance of mucosal expression of suppressors of cytokine signaling 1 (SOCS1) and SO......
目的探讨急性脑梗死(ACI)患者细胞因子信号转导抑制因子3(SOCS-3)及TNF-α和白细胞介素6(IL-6)水平变化的临床意义。方法选择发病......
AIM:To investigate if an immune imbalance may account for the development and progression of chronic radiation enteritis......
AIM: To study the expression of suppressor of cytokine signaling-1 (SOCS-1) in the liver tissues of chronic hepatitis B ......
目的研究活动期多发性肌炎患者外周血白细胞细胞因子信号转导蛋白抑制因子(SOCS)1、SOCS2、SOCS3和细胞因子诱导的含SH2区域蛋白1(......
目的:探讨SOCS-3在非酒精性脂肪肝病(NAFLD)发病中的作用以及吡格列酮的干预作用。方法:29只雄性SD大鼠随机分为正常对照组(8只),......
Effects of CpG-ODNs on phenotype and function of monocyte-derived dendritic cells in chronic hepatit
AIM:To study the effects of synthetic nonmethylated CpG-containing oligodeoxynucleotides(CpG-ODNs) ,either alone or comb......
BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor lea......
目的研究胰岛素样生长因子-(1IGF-1)与碱性成纤维细胞生长因子(FGF-2)对神经细胞增殖与分化的共同作用,并探讨SOCS基因表达与二者......
Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation o
AIM: To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic gen......
皮肤T细胞淋巴瘤的经典类型是蕈样肉芽肿和Sézary综合征。近年来,其发病率有逐渐增高的趋势。目前国内外从不同角度对该病的分子......
目的研究金欣口服液对呼吸道合胞病毒(RSV)感染的BALB/c小鼠肺组织中TLR3信号转导通路负调控因子SOCS1不同时间点的表达趋势的调控......
